Many Creation http://manycreation.com/ Thu, 22 Jul 2021 18:33:04 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 http://manycreation.com/wp-content/uploads/2021/04/many-creation-icon-150x150.png Many Creation http://manycreation.com/ 32 32 Shares of Absci protein discovery platform make market debut – TechCrunch http://manycreation.com/shares-of-absci-protein-discovery-platform-make-market-debut-techcrunch/ http://manycreation.com/shares-of-absci-protein-discovery-platform-make-market-debut-techcrunch/#respond Thu, 22 Jul 2021 18:28:01 +0000 http://manycreation.com/shares-of-absci-protein-discovery-platform-make-market-debut-techcrunch/

Absci Corp., a Vancouver-based company behind a multi-faceted drug development platform, went public on Thursday. This is another sign of the growing interest in new approaches to drug development – a traditionally risky business.

Absci focuses on accelerating drug development in preclinical stages. The company has developed and acquired a handful of tools that can predict drug candidates, identify potential drug targets, and test therapeutic proteins on billions of cells and identify those worth pursuing.

“We provide a fully integrated end-to-end solution for pharmaceutical drug development,” Absci founder Sean McClain told TechCrunch. “Think of it like searching the Google indexes for the discovery and biofabrication of protein drugs.”

The IPO was initially priced at $ 16 per share, with a pre-currency valuation of around $ 1.5 billion, by deposit S-1. The company is offering 12.5 million common shares and plans to raise $ 200 million. However, Absci stock has already swelled to $ 21 per share at the time of writing. The common shares trade under the symbol “ABSI”.

The company has chosen to go public now, McClain says, to increase the company’s ability to attract and retain new talent. “As we continue to grow and evolve rapidly, we need access to top talent, and the IPO gives us incredible visibility for talent acquisition and retention,” says McClain.

Absci was founded in 2011 with a focus on the manufacture of proteins in E.Coli. In 2018, the company launched its first commercial product called SoluPro – a biogenerated E.Coli system that can build complex proteins. In 2019, the company stepped up this process by implementing a “protein printing” platform.

Since its inception, Absci has grown to 170 employees and raised $ 230 million – the most recent inflow was a $ 125 million cross-funding round that closed in June 2020 led by Casdin Capital and Redmile Group. But this year, two major acquisitions completed Absci’s offering, from protein manufacturing and testing to AI-activated drug development.

In January 2021, Absci acquired Denovium, a company using deep learning AI to categorize and predict protein behavior. Denovium’s “engine” had been driven on more than 100 million proteins. In June, the company also acquired Totient, a biotechnology company that analyzes the immune system’s response to certain diseases. At the time of the Totient acquisition, the company had already reconstructed 4,500 antibodies gleaned from immune system data from 50,000 patients.

Absci already had protein manufacturing, evaluation and screening capabilities, but the acquisition of Totient enabled it to identify potential targets for new drugs. The Denovium acquisition added an AI-based engine to aid in protein discovery.

“What we are doing now is feeding [our own data] in deep learning models and that’s why we acquired Denovium. Before Totient, we were doing drug discovery and cell line development. This [acquisition] allows us to be fully integrated where we can now also do target discovery, ”said McClain.

These two acquisitions place Absci in a particularly active niche in the world of drug development.

For starters, there has been notable fiscal interest in developing new drug development approaches, even after decades of poor drug R&D returns. In the first half of 2021, Assess have reported that developers of new drugs have raised $ 9 billion in IPOs on Western Stock Exchanges. This despite the fact that drug development is traditionally high risk. R&D returns for biopharmaceuticals hit a record low of 1.6% in 2019 and rebounded to just around 2.5%, a 2021 Deloitte report notes.

In the world of drug development, we’ve seen AI play an increasingly important role. This same Deloitte report notes that “most biopharmaceutical companies attempt to integrate AI into drug discovery and development processes.” And, drug discovery projects received the largest amount of AI investment in 2020, according to the Stanford University Artificial Intelligence Index. Annual Report.

More recently, the prospects for using AI in drug development have been bolstered by companies that have taken a candidate through preclinical development stages.

In June, Insilico Medicine, a Hong Kong-based start-up, announced that it had brought an AI-identified drug candidate for idiopathic pulmonary fibrosis through the stages of preclinical testing – a feat that helped shut down a $ 255 Million Series C Round. Founder Alexander Zharaonkov told TechCrunch that the PI drug will begin a clinical trial of the drug at the end of this year or early next year.

With a hand in AI and protein manufacturing, Absci has already positioned itself in a crowded space, but filled with hype. But in the future, the company will still have to define the details of its business model.

Absci pursues a business model of partnership with drug manufacturers. This means that the company does not intend to conduct its own clinical trials. Rather, it expects to earn income through “milestone payments” (subject to reaching certain milestones in the drug development process) or, if drugs are approved, royalties on sales.

This offers some advantages, McClain says. The company is able to avoid the risk of drug candidate failure after millions of R&D dollars have been invested in testing and can invest in the development of “hundreds” of drug candidates at a time.

At this point, Absci currently has nine “active programs” with drug manufacturers. The company’s cell line manufacturing platforms are used in drug testing programs at eight biopharmaceutical companies, including Merck, Astellas and Alpha Cancer technologies (others are withheld). Five of those projects are in the preclinical stage, one is in phase 1 clinical trials, one is in phase 3 clinical trial and the last one is focused on animal health, according to the company’s S-1 dossier.

One company, Astellas, is currently using Absci’s discovery platforms. But McClain notes that Absci has only just deployed its drug discovery capabilities this year.

However, neither of these partners has officially licensed any of Absci’s platforms for clinical or commercial use. McClain notes that all nine active programs have milestones and royalty “potentials” associated with them.

The company has a long way to go in terms of profitability. So far this year, Absci has generated total revenue of around $ 4.8 million, up from around $ 2.1 million in 2019. Nonetheless, costs have remained high and S-1 records indicate that the company has suffered net losses over the past two years. In 2019, the company reported $ 6.6 million in net losses in 2019 and $ 14.4 million in net losses in 2020.

The company’s S-1 attributes these losses to expenses related to research and development costs, building an intellectual property portfolio, hiring staff, raising capital and supporting these. activities.

Absci recently completed construction of a 77,000 square foot facility, McClain notes. Thus, in the future, the company foresees the potential to increase the scale of its operations.

In the immediate future, the company plans to use the money raised during the IPO to increase the number of programs using Absci’s technology, invest in R&D and continue to refine new products based on it. Company AI.

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SF Supes envisions new bespoke bins costing up to $ 20,000 per can http://manycreation.com/sf-supes-envisions-new-bespoke-bins-costing-up-to-20000-per-can/ http://manycreation.com/sf-supes-envisions-new-bespoke-bins-costing-up-to-20000-per-can/#respond Thu, 22 Jul 2021 18:27:31 +0000 http://manycreation.com/sf-supes-envisions-new-bespoke-bins-costing-up-to-20000-per-can/

The latest town hall boondoggle is on a long-standing project to replace city street trash cans, and this week a committee of the supervisory board approved a proposal to make 15 prototype trash cans for testing. on the streets later this year. But because these are custom designs, every prototype comes at a steep price.

San Francisco usually can’t make anything easy if its life depended on it, and this trash can project is no exception. The problem is a widely accepted hatred for the round, dark green, historic-looking trash cans with the top sections still broken for recycling, which date back to 1993. Supervisors blame these easily broken and stolen cans for all of the extra trash in it. city ​​streets, which may or may not be based on reality.

And, of course, the continued use of these bins seems to have something to do with the Mohammed Nuru scandal – like the Chronicle Notes Via supervisor Matt Haney, the former public works chief pushed back efforts to put new trash cans on the streets and approved a $ 5.2 million contract with a company called Alternative Choice LLC, which is linked to a family member of disgraced municipal contractor Walter Wong who last year pleaded guilty to money laundering and fraud charges.

Thus, under the direction of a new chief of public works, the interim director Alaric Degrafinried, the city contracts with the industrial design company of Oakland ICI (Institute for Creative Integration) to create the prototypes. The department took the advice of the public and the SF Arts Commission to narrow the possibilities down to three finalist models, pictured below.

The three finalists, via SF Dept. of Public Works

Each prototype has its pros and cons, with the “Salt & Pepper” model offering the same small top bin for recyclables as the city’s existing cans. The “Slim Silhouette” model may work better for narrower sidewalks and offers a recycling hole that will not be as easily accessible as the existing model. And the “Soft Square” offers a handle door to access the scraps for waste and recycling.

As the Chronicle explained when the trash can finalists were first unveiled last September, aesthetics are just one yardstick on which the recipients will be judged. Each model must have a sturdy hinged door that can be locked and accessed by Recology; and each must have a removable rolling bin inside that can be loaded onto Recology’s automatic emptying mechanism on their trucks.

But, with each model costing between $ 12,000 and $ 20,000 each to produce, you end up with titles like this from KTVU and this from the Chronicle – which are misleading, if only because the ultimate price per box will likely be much cheaper once they are mass produced.

As the Chronicle reports, the city has already gone from using the Bigbelly Solar Powered Compactor Canisters, 150 of which now dot the Tenderloin thanks in part to the Community Benefit District located there. Public Works says these cans, which cost around $ 4,000 a piece, break too easily and do not meet Recology criteria above. Nuru was fiercely against them, possibly for the aforementioned corruption motive.

When the can testing phase begins in November, already mass-produced bins for other cities will be tested alongside the three custom prototypes, five of each of which will be produced by HERE.

The trash can proposal, which has yet to be submitted to the board for approval, has a price tag of $ 537,000, which includes the 15 prototypes, 10 rolling interior bins, the purchase of existing models from elsewhere and the project management.

“$ 20,000 a can is ridiculous,” Haney told The Chronicle, but said he voted to move the proposal forward in the interests of the time.

“Our streets and sidewalks are messy and the cans we have now are part of the problem,” he says. “At this point, they’ve already come up with designs, we won’t buy time now to go back, but it’s really frustrating that they’ve taken that route.”

Existing models of trash cans in other cities would cost between $ 3,000 and $ 5,000 each, but Public Works staff said most are either too big for our sidewalks or have openings too easily accessible.

There is no doubt that the price will increase when the full board accepts the proposal.

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Pump maker loses bid to appeal Roche’s UK patent http://manycreation.com/pump-maker-loses-bid-to-appeal-roches-uk-patent/ http://manycreation.com/pump-maker-loses-bid-to-appeal-roches-uk-patent/#respond Thu, 22 Jul 2021 16:10:00 +0000 http://manycreation.com/pump-maker-loses-bid-to-appeal-roches-uk-patent/
Law360, London (July 22, 2021, 5:10 p.m. BST) – A London judge on Thursday denied medical device maker Insulet permission to appeal a ruling that pharmaceutical giant Roche did not prematurely start selling pumps tubeless insulin before patent expires.

Pat Treacy, serving as a High Court judge, concluded that Insulet had no real chance of overturning its previous ruling freeing Roche from patent infringement claims on its line of insulin pumps.

According to the ruling, Insulet planned to argue that every aspect of the judge’s previous ruling contained “an error in principle, law and / or interpretation.” The judge said if Insulet wanted to appeal these …

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Compulsory licensing in access to covid-19 vaccine by African countries http://manycreation.com/compulsory-licensing-in-access-to-covid-19-vaccine-by-african-countries/ http://manycreation.com/compulsory-licensing-in-access-to-covid-19-vaccine-by-african-countries/#respond Wed, 21 Jul 2021 13:33:02 +0000 http://manycreation.com/compulsory-licensing-in-access-to-covid-19-vaccine-by-african-countries/

introduction

At the end of 2019, humanity was faced with a new infectious disease caused by a new coronavirus, covid-19 which led, on March 11, 2020, to the World Health Organization (WHO) to declare the state of a global pandemic. .

The fight against this new virus required several technical innovations and, besides the vaccine, many inventions required patent protection: retroviral drugs, diagnostic tests or medical devices, such as ventilators are some of these. examples. However, the most visible face of this fight has been the vaccine, which has put pharmaceutical companies in a race for its development.

At the time of writing, vaccines from Pfizer-BioNTech, Moderna, AstraZeneca, Janssen, Sinovac (CoronaVac) and Sputnik are administered worldwide and most developed countries in Europe and then the United States of America, the Russia and China plan to obtain group immunity by the end of 2021.

This situation is only possible because of the economic power available to countries, either to develop vaccines or to buy the same ones. Unfortunately, none of these possibilities are viable when it comes to underdeveloped countries, a situation which is currently unfolding across Africa. Indeed, African countries are devastated by the covid-19 pandemic, however, the fight against the same is not as fair as the fight taking place in developed countries.

Covax Initiative

Access to vaccines by these countries is a problem that has found a solution in the Covax incentive, an international mechanism co-led by Gavi (The Vaccine Alliance), the Coalition for Epidemic Preparedness Innovations (CEPI) and the World Health Organization. health with the objective of accelerating the development and manufacture of vaccines against covid-19, and guaranteeing fair and equitable access for all countries of the world. The international mechanism plans to distribute two billion doses of vaccines until the end of the year to underdeveloped countries, and it has agreements with AstraZeneca, Pfizer-BioNTech and Moderna.

Ghana was the first African country to receive vaccines under the international Covax mechanism in February: 600,000 doses of the vaccine developed by AstraZeneca. Since then, Algeria, Malawi and Uganda have also received doses of the vaccine from the same laboratory. In early March, Rwanda was included in Pfizer-BioNTech’s vaccine batch under Covax. However, this situation is far from ideal, as the percentage of the population that currently has access to the vaccine in Africa is extremely small.

Many were the public statements of António Guterres, the current Secretary General of the United Nations, in which he criticized the “extremely unequal and unfair” distribution of vaccines and called for the solidarity of countries to join this international. mechanism. Thus, only a comprehensive strategic vaccination plan would avoid future mutations of the virus in countries where vaccination has not progressed and would make it possible to fight effectively against the virus. It is important to note that two mutations of the virus have taken place in Brazil and South Africa and it is certain that if the pandemic is combated on a global level, it would be possible to avoid future mutations which would only delay the recovery. economy of the country and the return to a certain normality.

Patent system and collision with the right to health

Access to pharmaceutical products, in particular access to covid-19 vaccines can also be solved by the application of intellectual property rules.

The vaccines currently administered are protected by patent. A patent is a right granted by the government, in which the inventor has the exclusive right to explore the invention for a period of 20 years. To be granted, the patent must meet certain requirements, including novelty, inventive step and industrial applicability. Pharmaceuticals protected by patent are sold at a higher cost relative to the cost of production, to compensate for the investment in I&D. The purpose of granting a patent is to promote technological and scientific progress by offering the inventor market exclusivity.

However, the patent system as it is conceived comes up against a commensurable ethical aspect: the right to health.

For this reason, the patent system is not strict and determines mechanisms allowing access to pharmaceutical products, especially vaccines protected by patents. The most relevant limitations and exceptions to the patent system can be invoked as follows:

  • Temporal and territorial limitation: patents are valid for a limited period of time and are only protected in the jurisdictions in which protection has been requested.
  • Private use of the patent without commercial purposes: there is no patent infringement when there is use by a third party of the invention for private purposes and without commercial purposes.
  • Experimental use does not constitute a patent infringement, provided the use is made in testing or for experimental purposes.
  • Exhaustion of right: the rights conferred by the patent do not allow the patent owner to prohibit any act relating thereto after the invention has been legally placed on the market by the patent owner.
  • Compulsory license: when a government allows someone else to produce a patented product or the patented process without the consent of the patent holder.

Compulsory license as a mechanism for accessing pharmaceutical products (vaccines)

As noted above, compulsory licensing is when a government allows someone else to produce a patented product or patented process without the consent of the patent holder.

The license may be granted when (i) there is a lack or insufficient exploration of the invention; (ii) there is a dependence on patents; or (iii) where there are reasons of public interest, in which public health is, of course, included.

The granting of compulsory licenses depends on a judgment of proportionality between the right to patent and public health, however, it has been indicated as the main instrument of access to patented medicines and vaccines.

Article 31 of the TRIPS Agreement allows countries to make arrangements for the granting of a compulsory license to third parties without the authorization of the patent owner and sets out certain conditions which must be taken into account when the granting of a compulsory license.


“Despite this legal mechanism that allows underdeveloped countries to access vaccines or other patented medicines, there is no record of African countries using the same during the covid-19 pandemic until today. hui. “


Until 2001, when the Doha Declaration was signed at a WTO ministerial conference, compulsory licenses were not eligible for export. This amendment allowed underdeveloped countries to import patent-protected pharmaceuticals under the issuance of a compulsory license. This was an extremely important amendment because underdeveloped countries would have the power to issue compulsory licenses, but would not have the capacity to produce pharmaceuticals. Under this amendment, these countries can import products from countries that have the capacity to produce the same ones. The Doha Declaration expressly mentions the importance of the amendment, recognizing “the seriousness of the public health problems which afflict many developing and least developed countries, particularly those resulting from HIV / AIDS, tuberculosis , malaria and other epidemics ”and that the“ TRIPS Agreement does not and should not prevent Members from taking action to protect public health ”.

Despite this legal mechanism that allows underdeveloped countries to access vaccines or other patented medicines, there is no record of African countries using the same during the covid-19 pandemic until today. . Indeed, only Israel issued a compulsory license for the importation of a retroviral drug (Kaletra), due to the inability of the patent holder to produce it.

Considering that the pandemic is still far from being brought under control, depending on the effectiveness of the Covax initiative or any other mechanism that could be used (has the raising of the rules of the TRIPS Agreement defended by some), it is possible that some African countries issue compulsory licenses to access covid-19 vaccines.

Use of compulsory licenses by African countries

The use of compulsory licenses by underdeveloped countries is not new. The Doha Declaration helped ensure that underdeveloped countries did not fear trade sanctions when issuing compulsory licenses on patented pharmaceuticals.

One example is Mozambique, which in 2004 issued a compulsory license for the importation of three retroviral drugs, lamivudine, stavudine and nevirapine, to combat the HIV / AIDS epidemic, given the rates of mortality and transmission at the time, which made Mozambique one of the 10 countries most affected by the disease. In the same year, further compulsory licenses were issued by the governments of Zambia and Swaziland for the same effect.

In 2005, in Cameroon, Ghana, Guinea and Eritrea, governments issued compulsory licenses for the importation of retroviral products to combat the HIV / AIDS pandemic.

This article originally appeared in China IP Magazine.

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Journeys of Discovery: Beautifully Shattered – Dismantling the Hate http://manycreation.com/journeys-of-discovery-beautifully-shattered-dismantling-the-hate-2/ http://manycreation.com/journeys-of-discovery-beautifully-shattered-dismantling-the-hate-2/#respond Wed, 21 Jul 2021 05:25:54 +0000 http://manycreation.com/journeys-of-discovery-beautifully-shattered-dismantling-the-hate-2/

Join correspondent Tom Wilmer in Little Rock, Arkansas for an interview with Robin White, National Park Service superintendent at Central High School National Historic Site, and Courtney Bradford, professor of black history and curator at Mosaic Templars Cultural Center.

White and Bradford challenge listeners to examine racial inequalities through the insightful and at times very touching experiences of two women who champion new ways of approaching the age-old problem of racism.

Together they discuss the everyday issues facing people of color, dissect the dark roots of intergenerational racism that continues to grow today, detail effective programs – from the local to the international level – that help unite all. peoples under the banner of the “human race”, and recognize the power of the fresh perspectives of children to make lasting change a reality.

They postulate that a meaningful dialogue among allies to change the status quo – accomplished not only by seeing others for who they are, without prejudice, but by developing soul-to-soul affirmations capable of melting hatred. White and Bradford poignantly affirm the power of every “beautiful” life that comes together, as a chorus of humanity, to celebrate each other and promote peace.

Journeys of Discovery underwriting support provided by Nashville’s Big Back Yard Economic Initiative has focused on rural communities in southwestern Tennessee and the Shoals area of ​​northern Alabama.

You are invited to subscribe to the Lowell Thomas Award-winning podcast travel show, Journeys of Discovery with Tom Wilmer, featured in the NPR Podcast Directory, iHeartRadio, Apple Podcast.

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Journeys of Discovery: Beautifully Shattered – Dismantling the Hate http://manycreation.com/journeys-of-discovery-beautifully-shattered-dismantling-the-hate/ http://manycreation.com/journeys-of-discovery-beautifully-shattered-dismantling-the-hate/#respond Wed, 21 Jul 2021 05:25:54 +0000 http://manycreation.com/journeys-of-discovery-beautifully-shattered-dismantling-the-hate/

Join correspondent Tom Wilmer in Little Rock, Arkansas for an interview with Robin White, National Park Service superintendent at Central High School National Historic Site, and Courtney Bradford, professor of black history and curator at Mosaic Templars Cultural Center.

White and Bradford challenge listeners to examine racial inequalities through the insightful and at times very touching experiences of two women who champion new ways of approaching the age-old problem of racism.

Together they discuss the everyday issues facing people of color, dissect the dark roots of intergenerational racism that continues to grow today, detail effective programs – from the local to the international level – that help unite all. peoples under the banner of the “human race”, and recognize the power of the fresh perspectives of children to make lasting change a reality.

They postulate that a meaningful dialogue among allies to change the status quo – accomplished not only by seeing others for who they are, without prejudice, but by developing soul-to-soul affirmations capable of melting hatred. White and Bradford poignantly affirm the power of every “beautiful” life that comes together, as a chorus of humanity, to celebrate each other and promote peace.

Journeys of Discovery underwriting support provided by Nashville’s Big Back Yard Economic Initiative has focused on rural communities in southwestern Tennessee and the Shoals area of ​​northern Alabama.

You are invited to subscribe to the Lowell Thomas Award-winning podcast travel show, Journeys of Discovery with Tom Wilmer, featured in the NPR Podcast Directory, iHeartRadio, Apple Podcast.

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Serena Williams emphasizes killer curves in bold bodycon dress and high heels propped up on a table http://manycreation.com/serena-williams-emphasizes-killer-curves-in-bold-bodycon-dress-and-high-heels-propped-up-on-a-table/ http://manycreation.com/serena-williams-emphasizes-killer-curves-in-bold-bodycon-dress-and-high-heels-propped-up-on-a-table/#respond Wed, 21 Jul 2021 04:30:00 +0000 http://manycreation.com/serena-williams-emphasizes-killer-curves-in-bold-bodycon-dress-and-high-heels-propped-up-on-a-table/

Serena Williams shows off her killer curves in a bold fitted dress and matching high heels as she served up a stunning model pose while leaning against a table.

23 Grand Slam champion Serena Williams has proven her credibility as a skilled tennis player so much that it wouldn’t be wrong to crown her queen of the court.

Along with his athletic achievements, Williams explored his fashionable side by introducing a remarkable fashion line known as the “S”. The brand owner is also excellent at picking the right yarns that fit her bold curves perfectly.

Serena Williams during Mubadala Tennis World Championship at Zayed Sports City International Tennis Center in Abu Dhabi, United Arab Emirates on December 30, 2017 | Photo: Getty Images

Recently, Williams amazed fans by wearing a uniquely designed thin sleeve bodycon midi dress with a pair of matching heels.

The tennis champion’s ensemble accentuated her killer curves and offered a way to flaunt her toned arms and legs.

Williams struck a fierce model pose, tilting her hips to one side, leaning lightly on a table behind her and boldly gazing at the shutters while revealing a mix of sultry makeup and wavy blonde hair.

The caption accompanying the photo meant that it must have hit an official location with the bold appearance. He Lily:

“* ends the last meeting of the week *.”

Thousands of fans jumped at the heart icon on the post; they went further to express their thoughts via the comments section, applauding the tennis icon’s choice of outfit and her daring body.

CONFIDENCE DESPITE BODY SHAMING

Being in the spotlight means being famous, but most public figures and celebrities are too often scrutinized by the media’s eagle eyes.

Despite Williams’ achievements in the sport and unbeatable records, the four-time Olympic medalist has fallen prey to critics who shamefully comment on her.

These trolls abandon her impressive works and attack her physique, describing her as masculine. Even her fellow athlete, a former opponent, Caroline Wozniacki, once made a nasty move by inserting extra padding into her clothes to mimic Williams’ body.

The tennis star admitted that these things happened to her at some point in her life, especially since she was often compared to her sister Venus, a tennis player whom she claims to be slim and tall, with a different frame.

Still, the four-time gold medalist overcame criticism by turning a deaf ear and being happy with her figure. She impacted many women by making them accept their bodies with pride, and the athlete guided her audience with her confidence displayed both online and offline.

Body-hugging outfits aren’t the only way the 39-year-old shows her confidence. She also likes to show a little skin every now and then.

In 2019, Williams dazzled her audience by sharing bikini pics and a video where she spent girls time with Venus on a yacht; and fans have dropped many admirable comments.

THE SUPPORT SHE RECEIVES

Fans aren’t the only ones to praise Williams’ appearance or appearance. Her husband, Reddit co-founder Alexis Ohanian, not only compliments but shows unwavering support for his leading wife.

The entrepreneur applauds online trolls or anyone with a callous comment. After a former Romanian tennis player, Ion Tirac, shames Williams and asks him to retire due to his aging body.

Alexis fought back Going through a tweet announcing that Ion’s opinions don’t matter; his file does not match that of his wife either.

SERENA AS A MODEL

Williams and Alexis share a baby girl named Olympia Ohanian. While speaking of excluding critics, the mother of a mentionned that his child inherited his strong arms and expressed his intention to teach the little servant how to appreciate his body.

Since her birth, Olympia has paired up in creative creations with her mom and seems to be the fashion icon of the century! In March, mother and daughter debuted their very first fashion campaign, “Footsteps To Follow”.

These were the ladies rocking Stuart Weitzman’s spring 2021 collection, from jumpsuits, maxi dresses and matching animal print sandals. Olympia seems to be seduced by fashion and, like her mother, she is confident when it comes to donning unique models!


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]]> http://manycreation.com/serena-williams-emphasizes-killer-curves-in-bold-bodycon-dress-and-high-heels-propped-up-on-a-table/feed/ 0 Ergonomics problems lead to the invention for fishermen http://manycreation.com/ergonomics-problems-lead-to-the-invention-for-fishermen/ http://manycreation.com/ergonomics-problems-lead-to-the-invention-for-fishermen/#respond Wed, 21 Jul 2021 04:22:00 +0000 http://manycreation.com/ergonomics-problems-lead-to-the-invention-for-fishermen/
Invercargill man Brian Smith with his patented invention, the Rodassista, to help people use their fishing rods.

Robyn Edie / Stuff

Invercargill man Brian Smith with his patented invention, the Rodassista, to help people use their fishing rods.

A Southland fisherman has created a device that he says will help with fishing ergonomics.

In 2010, Brian Smith noticed that he and others were having issues with their arms, backs, and legs because the tips of their fishing rods weren’t standing still.

Smith decided to search the market for a solution but couldn’t find anything, so he took it upon himself to create something.

He invented a strap device that would hold the end of the fishing rod stationary, thus stopping the pressures on the arms and back from the constant movement.

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His Rodassista was in his cupboard collecting dust until 2016, when Smith suffered a heart attack.

“Due to professional commitments, I put it aside. When I got sick I took it out again because I had a lot of free time, ”he said.

Smith has had two hip replacements and a stroke since his heart attack, so he devoted himself to his invention.

He teamed up with plastic engineer Graeme Rickard and created Innovative Fishing Equipment, the Rodassista being their flagship item but also offering other equipment for fishermen.

The company spent four months researching if something like the Rodassista existed in the world and found nothing like it and was therefore able to patent it internationally, Smith said.

Invercargill man Brian Smith with his patented invention, the Rodassista, to help people use their fishing rods.

Robyn Edie / Stuff

Invercargill man Brian Smith with his patented invention, the Rodassista, to help people use their fishing rods.

According to Smith, 80% of the sticks will be suitable for the invention, and they also have a chiropractor reviewing them.

“I’m really proud of what we’ve done. I know people who are now going to go fishing and try this, and they haven’t been able to fish for years because of the pain, but they want to come for a ride, ”he said.

The company plans to sell online as a first step and attend numerous trade shows, such as the Southland Boat Show, to demonstrate how the product works before moving on to retail and wholesale.

Smith intends to market his product worldwide and is expected to launch the product in the markets in August.

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Chip and Joanna Gaines Celebrate New York Magnolia Network Launch http://manycreation.com/chip-and-joanna-gaines-celebrate-new-york-magnolia-network-launch/ http://manycreation.com/chip-and-joanna-gaines-celebrate-new-york-magnolia-network-launch/#respond Wed, 21 Jul 2021 02:05:00 +0000 http://manycreation.com/chip-and-joanna-gaines-celebrate-new-york-magnolia-network-launch/

Chip and Joanna Gaines celebrate the launch of Magnolia Network in New York City at a chic party at the Polo Bar in Manhattan with Discovery CEO David Zaslav.

Chip and Joanna Gaines from the hit show HGTV Upper Fixator celebrated the launch of their Magnolia network in New York. For five successful seasons, the duo have helped couples find homes to renovate in their dream home. The couple announced their intention to launch Magnolia Network in 2019, which never happened due to the COVID-19 pandemic. Fixers have since replaced the DIY Network with the launch of Magnolia Network.

Chip and Joanna have drawn 75 million viewers after five seasons of Upper fixer. The popular couple made the dreams of many families come true, but they revealed that they need to take care of their own families. Chip and Joanna shared that they felt exhausted after six years of filming the show while raising their children. The couple took a year-long hiatus from the show to reconsider whether working with HGTV still fulfilled them.

Related: Fixer Upper: Chip & Joanna Gaines’ Relationship Timeline

According to Sixth page, the Upper Fixator couple celebrated the launch of Magnolia Network last week in New York City. Guests supporting the launch showed up at the Polo Bar in Manhattan. The Magnolia network is available through Discovery +. It would make sense that Discovery CEO David Zaslav was also spotted at the Polo Bar party. The other participants were: Allison Page, Clint Harp, Abner Ramirez, Amanda Sudano and Andrew Zimmern. Of course, a flower wall with the network logo has been set up for guests to take selfies and group photos. For Chip and Joanna, the celebration didn’t end at the private event. The pair have been seen splurging at designer stores. Joanna, in particular, was spotted at Roman and Williams Guild, where a source said she stayed for at least an hour.

Even after their hiatus, Chip and Joanna still have a passion for what they’re doing on Upper fixer. According to the Magnolia Network website, the couple will continue to shoot new episodes of Secure Upper Welcome Home. The Magnolia Network seems like the perfect streaming service for craft and storytelling enthusiasts. Some of the shows that will air include The lost kitchen, House, and The Restoration Route with Clint Harp. Joanna and Chip are able to explore distinct interests, as they each have their own shows on the networks. The chip can be seen in The courage to run with Chip Gaines and Gabe Grunewald, while Joanna will take on a new role in Magnolia Table With Joanna Gaines.

the Upper Fixator couple attracted 19 million viewers each week on the HGTV show. Although Magnolia Network is only available through Discovery +, the couple are sure to attract fans with the diversity of their shows. With the launch of their new network and the education of their children, Chip and Joanna Gaines are making things easy.

Next: Joanna Gaines Reveals Impact Of Discrimination Charges On Her Life

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Shark Bites New Viewers For Discovery In 33rd Grade | Entertainment News http://manycreation.com/shark-bites-new-viewers-for-discovery-in-33rd-grade-entertainment-news/ http://manycreation.com/shark-bites-new-viewers-for-discovery-in-33rd-grade-entertainment-news/#respond Tue, 20 Jul 2021 22:16:00 +0000 http://manycreation.com/shark-bites-new-viewers-for-discovery-in-33rd-grade-entertainment-news/

By DAVID BAUDER, AP Media Editor

NEW YORK (AP) – Shark Week just wrapped up its 33rd edition on Discovery, a televised event so old that an advertiser joked that he could have his own children.

But some recent research has illustrated its ability to attract new viewers to the network, something increasingly important at a time when TV networks and streaming services are furiously competing for their eyes.

An LG Ads study found that during Shark Week last year, 37% of people who logged in hadn’t watched Discovery at any time in the past month. This phenomenon was most pronounced for National Geographic Explorer’s Shark Fest, where 51% of viewers had not seen the network in the previous month.

For both networks, more than a third of these new viewers returned for other shows in the following month.

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“In a world where the cable doesn’t automatically turn on when you turn on your TV, this is just incredibly important,” said Justin Fromm, executive at LG Ads.

It’s the definition of event programming, which networks use to advertise their products – as NBC Universal networks will do starting Friday with the Olympics.

National Geographic Explorer has actually extended Shark Fest over six weeks, starting earlier this month. The programming was also made available on the Disney + streaming service.

Discovery shows averaged 687,000 prime-time viewers last week, oddly lower than the week before, although there was competition from the NBA Finals and the All-Star Game. baseball. The first night of Shark Week, July 11, is the most popular and was counted in Nielsen Company figures for the past week. Viewing increased among viewers aged 18 to 49, an indication that the network’s audience makeup was different from typical weeks.

Boasting their sporting events, ABC attracted an average of 4.1 million prime-time viewers last week and Fox 2.9 million. NBC had 2.6 million, CBS 2.4 million, Univision 1.6 million, Ion Television 1.1 million, and Telemundo 1 million.

Fox News Channel dominated cable networks, averaging 2.13 million prime-time viewers. ESPN had 1.35 million, MSNBC 1.28 million, HGTV 1.23 million, and Hallmark 1.01 million.

ABC’s “World News Tonight” led the race for evening news ratings, averaging 7.6 million viewers. NBC’s “Nightly News” had 6.1 million viewers and “CBS Evening News” had 4.7 million.

For the week of July 12 to 18, the 20 most watched programs, their networks and their audiences:

1. NBA Finals: Phoenix in Milwaukee, Game 4, ABC, 10.26 million.

2. NBA Finals: Milwaukee to Phoenix, Game 5, ABC, 9.62 million.

3. Baseball: All-Star Game, Fox, 9.62 million.

4. “America’s Got Talent,” NBC, 7.1 million.

5. “Home Run Derby,” ESPN, $ 6.29 million.

6. “60 minutes”, CBS, 5.96 million.

7. “Celebrity Family Feud,” ABC, 4.84 million.

8. “America’s Funniest Home Videos,” ABC, 3.95 million.

9. “NCIS”, CBS, 3.925 million.

10. “Home Run Derby Prelude”, ESPN, 3.925.

11. “The Chase”, ABC, 3.83 million.

12. “Big Brother” (Thursday), CBS, 3.81 million.

13. “The Bachelorette”, ABC, 3.71 million.

14. Football: Mexico against El Salvador, Univision, 3.64 million.

15. “Big Brother” (Wednesday), CBS, 3.63 million.

16. “NBA Countdown” (Wednesday), ABC, 3.5 million.

17. “Big Brother” (Sunday), CBS, 3.49 million.

18. “The Neighborhood,” CBS, 3.36 million.

19. “American Ninja Warrior”, NBC, 3.32 million.

20. “To Tell the Truth,” ABC, 3.26 million.

Copyright 2021 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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