New ALS Discovery Highlights Possible Treatment Path

A recently discovered intracellular process in amyotrophic lateral sclerosis (ALS) may be the starting point for developing new treatments for the disease, new research shows.

The research, which was led by Professor Eran Perlson of the Department of Physiology and Pharmacology at Tel Aviv University, was published in the EMBO Journal June 30.

Research has found that the CRMP4 proteins associated with ALS cause loss of motor neurons by acting as a “death signal”. This suggests that blocking this process, whether through genetic or pharmacological means, may reduce symptoms of ALS.

As part of the research, a biochip was developed to study how ALS destroys motor neurons and the musculoskeletal system. The researchers then used the system to grow and sort the stem cells into nerve cells. They were able to use these cells to study the process of nerve cell death in ALS.

“Our discovery provides new encouragement for the development of treatments for ALS,” said Professor Perlson. “This could open up new avenues for research into the long-term communication between different nerve regions that are essential to better understand the pathological processes of ALS.

ALS is a neurodegenerative disease in which the brain loses control of the muscles in the body. Within two to five years, patients lose their ability to move, speak, eat, and ultimately breathe. The disease is devastating and affects approximately 450,000 people worldwide.

Over the past few years, experts have made significant strides in ALS research, but as of yet, the exact cause is unknown and there is no cause or effective treatment.

The development this research presents is important for the understanding needed to reach discoveries that will be important in finding a cure or a cure, but the researchers said the prospect of concrete treatment development is still years away.

There is still a lot of progress to be made, but each new light in the field brings hope and a step forward.

The research was conducted by Dr Roy Maimon and Lior Ancol of Professor Perlson’s lab with Tal Gardus Pery, Topaz Altman and Ariel Ionescu. Other attendees included Professor Martin Ballastik from the Czech Academy of Sciences, Professor Sami Baramada from the University of Michigan, Dr Amir Dori from Sheba Medical Center in Tel Hashomer and Professor Yarden Opatowsky from Bar University. Ilan.

The study:

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